Antifungal Activity of Ring Poly-Chlorinated Pyrimidines: Structure Activity Relationships
نویسندگان
چکیده
منابع مشابه
Structure-activity relationships of new aranorosin analogs to antifungal activity.
prepared by stirring a mixture of 1 with the corresponding carboxylic acid (1.1 equiv.) in the presence of dicyclohexylcarbodiimide (DCC) (1.1 equiv.) and 4-dimethylaminopyridine (DMAP) (0.1 equiv.) in CH2Cl2 at room temperature for 24 hours. The crude products, obtained after usual work up, were purified by preparative TLC on silica gel (Article No. 13794, E. Merck) using CHCl3 MeOH (9:1) as t...
متن کاملStructure-activity relationships of the cycloalkyl ring of phencyclidine.
In order to investigate the structural requirements for a cycloalkyl moiety in the potent hallucinogen 1-(1-phenylcyclohexyl)piperidine (PCP, 1), a series of structural analogues was synthesized in which the size of the cycloalkyl ring was varied from three carbons to eight carbons. Biological activities of these compounds were assessed in an in vitro assay (phencyclidine binding assay) and an ...
متن کاملStructure-radical scavenging activity relationships of hydroxytoluene derivatives
Research works proposed that radical scavenging activity of flavonoids is due to ring B, andthe remaining part of the molecule can be disregarded. Thus the objective of this work is toobserve whether hydroxytoluenes account the radical scavenging activity of flavonoid and toestablish structural requirements for their activity (as they showed appreciable activity) andelucidate a comprehensive me...
متن کاملSynthesis, Structure-Activity Relationships (SAR) and in Silico Studies of Coumarin Derivatives with Antifungal Activity
The increased incidence of opportunistic fungal infections, associated with greater resistance to the antifungal drugs currently in use has highlighted the need for new solutions. In this study twenty four coumarin derivatives were screened in vitro for antifungal activity against strains of Aspergillus. Some of the compounds exhibited significant antifungal activity with MICs values ranging be...
متن کاملStructure-Activity Relationships for the Antifungal Activity of Selective Estrogen Receptor Antagonists Related to Tamoxifen
Cryptococcosis is one of the most important invasive fungal infections and is a significant contributor to the mortality associated with HIV/AIDS. As part of our program to repurpose molecules related to the selective estrogen receptor modulator (SERM) tamoxifen as anti-cryptococcal agents, we have explored the structure-activity relationships of a set of structurally diverse SERMs and tamoxife...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1963
ISSN: 0003-6919
DOI: 10.1128/aem.11.2.78-83.1963